Progesterone and norethisterone have different effects on tachykinin-like immunoreactivity in rat cortex and striatum |
| |
Authors: | Rugarn O Hammar M Theodorsson E |
| |
Affiliation: | Faculty of Health Sciences, Division of Obstetrics and Gynecology, Link?ping University Hospital, S-581 85, Link?ping, Sweden. mats.hammar@kkl.us.lio.se |
| |
Abstract: | OBJECTIVE: The purpose of this study was to investigate the effects of progesterone and the most commonly prescribed synthetic progestogen, norethisterone, on regional immune-like reactivity of neuropeptide Y (NPY), substance P (SP), neurokinin A (NKA) and neurotensin (NT) in brains of female ovariectomized estradiol-substituted rats. Results: Norethisterone+estradiol-treated rats had 44% lower SP levels compared with estradiol-only-treated in frontal cortex and 20% lower NKA levels in comparison with progesterone+estradiol-treated in frontal cortex. Progesterone+estradiol-treated rats had 66% lower SP levels in striatum in comparison with both estradiol-only-treated and norethisterone+estradiol-treated. No significant results were found for NPY and NT. CONCLUSION: Progesterone and the synthetic progestogen, norethisterone, have different effects on SP- and NKA-like immunoreactivity in rat cortex and striatum.The effects of NET on SP- and NKA-like immunoreactivity in frontal cortex may contribute to the mood effects ascribed to this progestogen in clinical usage. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|