Somatostatin inhibits growth of rainbow trout |
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Authors: | NM Very D Knutson J D Kittilson M A Sheridan |
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Institution: | Department of Zoology and Regulatory Biosciences Center, North Dakota State University, Fargo, ND 58105, U.S.A. |
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Abstract: | Implantation of rainbow trout Oncorhynchus mykiss with somatostatin-14 (SS-14) for 20 days resulted in reduced food conversion as well as significant growth retardation compared to controls. Relative growth as mass was reduced by 20%, whereas relative growth by length was reduced by 45%. A single intraperitoneal injection of SS-14 reduced plasma levels of growth hormone (GH), insulin-like growth factor-1 (IGF-I) and insulin. SS-14 injection also reduced 35S]-sulphate incorporation into gill cartilage compared to saline-injected fish. In addition, in vitro incubation of gill cartilage with SS-14 reduced 35S]-sulphate incorporation in a doserelated manner. These results indicate that SS-14 inhibits growth of rainbow trout and suggests that SS-14, in addition to influencing GH, may play an extra-pituitary role in the modulation of the GH-IGF-I axis. |
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Keywords: | somatostatin growth hormone insulin-like growth factor-I [35S]-sulphate incorporation |
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