Mescaline-induced changes of brain-cortex ribosomes. Effect of mescaline on the stability of brain-cortex ribosomes |
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| Authors: | R K Datta and J J Ghosh |
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| Institution: | Division of Laboratories, Beth Israel Medical Center, New York, N.Y. 10003, U.S.A., and Department of Biochemistry, University College of Sciences, Calcutta University, Calcutta 19, India |
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| Abstract: | 1. During the action of mescaline sulphate on goat brain-cortex slices the ribosomal particles become susceptible to breakdown, releasing protein, RNA, acidsoluble nucleotides and ninhydrin-positive materials, resulting in loss of ribosomal enzyme activities. 2. Ribosomes of the mescaline-treated cortex slices undergo rapid degradation in the presence of trypsin and ribonuclease. 3. Mescaline does not alter the chemical and nucleotide compositions or the u.v.-absorption characteristics of ribosomal particles, however. |
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