Effects of alpha- and beta-tigogenin cellobiosides on cholesterol absorption |
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| Authors: | M R Malinow J O Gardner J T Nelson P McLaughlin B Upson R Aigner-Held |
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| Institution: | Laboratory of Cardiovascular Diseases, Oregon Regional Primate Research Center, Beaverton 97006. |
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| Abstract: | We have synthesized alpha- and beta-anomers of tigogenin cellobioside and have determined their effects on intestinal absorption of 1,2-3H]cholesterol in rats. We demonstrated that the loss of tritium label likely to occur in the conversion of cholesterol to coprostanone was minimal. Dose response studies showed that both anomers depressed intestinal absorption of cholesterol but the depression was greater with the beta-anomer. |
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