Macrocarpones,novel metabolites from stromata of <Emphasis Type="Italic">Hypoxylon macrocarpum</Emphasis>, and new evidence on the chemotaxonomy of <Emphasis Type="Italic">Hypoxylon</Emphasis> species |
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Authors: | Andrea?Mühlbauer Dagmar?Triebel Derek?Persoh Hartmund?Wollweber Stephan?Seip Email author" target="_blank">Marc?StadlerEmail author |
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Institution: | 1.Bayer AG, Pharma Research Europe,Life Science Center Natural Products,Wuppertal,Germany;2.Department of Mycology,Botanische Staatsammlung München,München,Germany;3.Lehrstuhl für Pflanzensystematik,Universit?t Bayreuth,Bayreuth;4.Naturwissenschaftlicher Verein Wuppertal,Wuppertal |
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Abstract: | Several species of the genus Hypoxylon (Xylariaceae) were studied for morphological characters and HPLC-based secondary metabolite profiles. It was confirmed that
Hypoxylon is divided into two groups of species, containing either Mitorubrin type azaphilones or binaphthyls, respectively, as main
metabolites. In Hypoxylon species of the latter group, some metabolites that are known from the allied genus Daldinia (i.e., Daldinal A in H. fuscum and Daldinin C in H. fuscopurpureum), were encountered for the first time. Moreover, three novel aromatic polyketides, for which the trivial names Macrocarpones
A, B and C are proposed, were isolated from ascostromata of Hypoxylon macrocarpum and identified by high resolution mass spectrometry and 2D-NMR spectroscopy. Orsellinic Acid was also identified from ascostromata
of H. howeianum and detected by HPLC-MS and HPLC-UV/Vis fingerprinting methodology in H. fragiforme and H. rubiginosum, but not in other examined Hypoxylon species. Due to these studies, H. fuscopurpureum sensu Y.-M. Ju & J.D. Rogers 1996 was identified as a new record for Germany. |
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