ReseqChip: Automated integration of multiple local context probe data from the MitoChip array in mitochondrial DNA sequence assembly |
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| Authors: | Marian Thieme Claudio Lottaz Harald Niederst?tter Walther Parson Rainer Spang and Peter J Oefner |
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| Institution: | (1) Institute of Functional Genomics, University of Regensburg, Josef-Engert-Str. 9, D-93053 Regensburg, Germany;(2) Institute of Legal Medicine, Innsbruck Medical University, Muellerstrasse 44, A-6020 Innsbruck, Austria |
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| Abstract: | Background The Affymetrix MitoChip v2.0 is an oligonucleotide tiling array for the resequencing of the human mitochondrial (mt) genome.
For each of 16,569 nucleotide positions of the mt genome it holds two sets of four 25-mer probes each that match the heavy
and the light strand of a reference mt genome and vary only at their central position to interrogate all four possible alleles.
In addition, the MitoChip v2.0 carries alternative local context probes to account for known mtDNA variants. These probes
have been neglected in most studies due to the lack of software for their automated analysis. |
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