Incorporation of 14C-mevalonate into biliary cholesterol and bile acids by perfused rat liver: Effect of plasma and individual lipoproteins |
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Authors: | MTRavi Subbiah |
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Institution: | Lipid Research Center University of Cincinnati Medical Center Cincinnati, Ohio 45267 USA |
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Abstract: | Effect of plasma and individual lipoproteins on the incorporation of 14C-mevalonate into biliary bile acids and cholesterol by perfused rat liver was investigated. Use of plasma free perfysate (instead of whole blood) gave similar rates of incorporation of 14 C-mevalonate into biliary bile acids, but showed a decrease in percent distribution in cholic acid and a increase in β-muricholic acid. Addition of VLDL (isolated from Zucker rats) into the plasma free perfusate caused a significant increase in the incorporation of the label into bile acids, but LDL and HDL had no effect. HDL caused an increase in biliary excretion of 14C-cholesterol. |
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