Low background,pulsatile, in vitro flow circuit for modeling coronary implant thrombosis |
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Authors: | Kolandaivelu Kumaran Edelman Elazer R |
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Institution: | Harvard-MIT Division of Health Science and Technology, Massachusetts Institute of Technology, 77 Massachusetts Ave. Bldg 16-343, Cambridge, MA 02139, USA. kkolanda@excite.com |
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Abstract: | We have developed an in vitro method for creating pulsatile flows to mimic coronary type flow patterns on a beat-to-beat basis. The flow is created by accelerating fluid loops about an axis, inducing relative wall motion. Using this technique, a variety of oscillating flow patterns can be generated and modulated. Such flow generation offers the potential to monitor sensitive, flow-dependent, biological parameters like thrombosis while minimizing background disturbances from pump action and circuit effects. We examined this potential by measuring the loop occlusion time for loops stented with stainless steel 7-9 NIR stents and stentless control loops. |
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