Genetics of body weight in the LXS recombinant inbred mouse strains |
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Authors: | Beth Bennett Phyllis J Carosone-Link Lu Lu Elissa J Chesler Thomas E Johnson |
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Institution: | (1) Institute for Behavioral Genetics, 447, University of Colorado at Boulder, Boulder, Colorado 80309-0447, USA;(2) Center of Genomics and Bioinformatics, Institute of Neuroscience, Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA;(3) Department of Integrative Physiology, 354, University of Colorado at Boulder, Boulder, Colorado 80309-0447, USA |
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Abstract: | This is the first phenotypic analysis of 75 new recombinant inbred (RI) strains derived from ILS and ISS progenitors. We analyzed
body weight in two independent cohorts of female mice at various ages and in males at 60 days. Body weight is a complex trait
which has been mapped in numerous crosses in rodents. The LXS RI strains displayed a large range of weights, transgressing
those of the inbred progenitors, supporting the utility of this large panel for mapping traits not selected in the progenitors.
Numerous QTLs for body weight mapped in single- and multilocus scans. We assessed replication between these and previously
reported QTLs based on overlapping confidence intervals of published QTLs for body weight at 60 days and used meta-analyses
to determine combined p values for three QTL regions located on Chromosomes 4, 5, and 11. Strain distribution patterns of microsatellite marker genotypes,
weight, and other phenotypes are available on WebQTL () and allow genetic mapping of any heritable quantitative phenotype measured in these strains. We report one such analysis,
correlating brain and body weights. Large reference panels of RI strains, such as the LXS, are invaluable for identifying
genetic correlations, GXE (Gene X Environment) interactions, and replicating previously identified QTLs.
Electronic Supplementary Material Electronic Supplementary material is available for this article at
and accessible for authorised users. |
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