Chemical protein synthesis |
| |
Authors: | Kochendoerfer G G Kent S B |
| |
Affiliation: | Gryphon Sciences, South San Francisco, CA 94080, USA. Gkochendoerfer@gryphonsci.com. |
| |
Abstract: | Since the mid-1990s, chemical synthesis has emerged as a powerful technique for the study of structure/function relationships in proteins. During the review period, the applicability of chemical protein synthesis techniques has been significantly broadened by increases in the size of synthetically accessible proteins through two new techniques: solid-phase protein synthesis and expressed protein ligation. Also in the period under review, synthetic access to novel classes of proteins has been established, including metalloproteins with tuned properties and integral membrane proteins. |
| |
Keywords: | Protein synthesis Solid-phase synthesis Protein ligation NMR X-ray crystallography Influenza A AOP-RANTES |
本文献已被 ScienceDirect PubMed 等数据库收录! |