A review on numerical modeling for magnetic nanoparticle hyperthermia: Progress and challenges |
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| Institution: | 1. Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran;2. School of Chemical Engineering, Iran University of Science and Technology, Tehran, Iran;3. Department of Resin and Additives, Institute for Color Science and Technology, Tehran, Iran;4. Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), Tehran, Iran;5. Cellular and Molecular Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran;6. Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran;1. National University of Science and Technology «MISiS», Moscow, Russia;2. Lomonosov Moscow State University, Moscow, Russia;3. National Medical Research Center for Psychiatry and Narcology, Moscow, Russia;4. School of Physics, Aristotle University of Thessaloniki, Thessaloniki, Greece;5. Medical Nanotechnology LLC, Skolkovo Innovation Center, Moscow, Russia;6. Faculty of Physics and Center for Nanointegration Duisburg-Essen, University of Duisburg-Essen, Duisburg, Germany;7. D. Mendeleev University of Chemical Technology of Russia, Moscow, Russia;8. Department of Medical Nanobiotechnology, Russian National Research Medical University, Moscow, Russia |
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| Abstract: | Recent progress in nanotechnology has advanced the development of magnetic nanoparticle (MNP) hyperthermia as a potential therapeutic platform for treating diseases. Due to the challenges in reliably predicting the spatiotemporal distribution of temperature in the living tissue during the therapy of MNP hyperthermia, critical for ensuring the safety as well as efficacy of the therapy, the development of effective and reliable numerical models is warranted. This article provides a comprehensive review on the various mathematical methods for determining specific loss power (SLP), a parameter used to quantify the heat generation capability of MNPs, as well as bio-heat models for predicting heat transfer phenomena and temperature distribution in living tissue upon the application of MNP hyperthermia. This article also discusses potential applications of the bio-heat models of MNP hyperthermia for therapeutic purposes, particularly for cancer treatment, along with their limitations that could be overcome. |
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| Keywords: | Cancer treatment Magnetic fluid hyperthermia Induction heating Specific loss power Bio-heat modeling Heat transfer analysis |
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