Circular RNA has_circ_0003204 inhibits oxLDL-induced vascular endothelial cell proliferation and angiogenesis |
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| Affiliation: | 1. The First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, China;2. Department of Emergency, The Affiliated Huai''an Hospital of Xuzhou Medical College and The Second People''s Hospital of Huai''an, Huai''an, China;3. Department of Cardiology, Jiangxi Provincial People''s Hospital Affiliated to Nanchang University, Nanchang, Jiangxi, China;4. Department of Critical Care Medicine, School of Medicine, Ruijin Hospital North, Shanghai Jiaotong University Shanghai, China;1. Departments of Surgery, University of Missouri School of Medicine, Columbia, MO, United States of America;2. Department of Medical Pharmacology & Physiology, University of Missouri School of Medicine, Columbia, MO, United States of America |
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| Abstract: | Circular RNAs (circRNAs) are widely expressed in eukaryotic cells and play a key role in atherosclerosis. The aim of this study is to explore the relationship between hsa_circ_0003204 and atherosclerosis. Here, hsa_circ_0003204 was aberrantly overexpressed in the ox-LDL-induced human umbilical vein endothelial cells (HUVECs). Knockdown of hsa_circ_0003204 facilitated the proliferation, migration, and invasion but reduced the apoptosis of oxLDL-induced HUVECs. Furthermore, hsa_circ_0003204 knockdown significantly reduced the E-cadherin expression but increased the expressions of N-cadherin and vimentin in oxLDL-induced HUVECs. Collectively, these findings suggest that hsa_circ_0003204 plays an important role in the proliferation and angiogenesis of HUVECs, providing a potential target for treating endothelial cell damage in atherosclerosis. |
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