Chemical constituents isolated from Valeriana officinalis L |
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| Affiliation: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People''s Republic of China;2. Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou 571101, People''s Republic of China;1. Faculty of Pharmacy, Department of Pharmacognosy, Istanbul University, Istanbul 34116, Turkey;2. Department of Pharmacy, Pharmaceutical Biology, Saarland University, Saarbrucken 66123, Germany;3. Experimental Pharmacology for Natural Sciences, Martin Luther University Halle-Wittenberg, Institute of Pharmacy, Halle 06120, Germany;4. Faculty of Pharmacy, Department of Pharmaceutical Technology, Istanbul University, Istanbul 34116, Turkey;5. USDA-ARS, Center for Medical, Agricultural, and Veterinary Entomology, 1700 SW 23rd Drive, Gainesville, FL 32608, USA;6. USDA-ARS, Subtropical Horticulture Research Station, 13601 Old Cutler Rd., Miami, FL 33158, USA;7. Faculty of Pharmacy, Department of Pharmacognosy, Anadolu University, Eskişehir 26470, Turkey;8. Faculty of Pharmacy, Department of Pharmaceutical Botany, Cukurova University, Adana 01330, Turkey;9. Faculty of Medicine, Department of Medical Pharmacology, Bahcesehir University, Istanbul 34734, Turkey;10. Faculty of Pharmacy, Department of Pharmacognosy, Acibadem Mehmet Ali Aydınlar University, Istanbul, Turkey;11. Near East University Faculty of Pharmacy, Department of Pharmacognosy, Near East University, Nicosia, Cyprus;1. Guang''anmen Hospital, China Academy of Chinese Medicine Science, Beijing 100053, China;2. Department of Pharmaceutical Chemistry, Beijing Institute of Radiation Medicine, Beijing 100850, China;3. Hubei University of Traditional Chinese Medicine, Wuhan 430062, Hubei, China |
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| Abstract: | Phytochemical investigations on the leaves of Valeriana officinalis L. led to the isolation of 18 compounds, including eight lignans (1–8), three sesquiterpenoids (9–11), five iridoids (12–16), and two aldehydes (17–18) The structure elucidation of isolated compounds was achieved on the basis of NMR and mass spectral data. Among them, three compounds (9–16, 18) are reported from V. officinalis for the first time and one compound (5) was isolated from the genus Valeriana for the first time. In addition, six compounds (2, 4, 6–8, 17) are isolated for the first time from Valerianaceae family. The chemotaxonomic significance of these isolated compounds has also been discussed. |
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| Keywords: | Valerianaceae Sesquiterpenoids Chemotaxonomy |
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