Secondary metabolites produced by mangrove endophytic fungus Aspergillus fumigatus HQD24 with immunosuppressive activity |
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| Institution: | 1. Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Organization of African Unity Street 1, 11566 Cairo, Egypt;2. Center for Drug Discovery and Development Research, Ain-Shams University, Abassia, 11566 Cairo, Egypt;3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mu’tah University, 61710 Al-Karak, Jordan;4. Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, 35516 Mansoura, Egypt;5. Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany;1. CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China;2. Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China;3. Laboratory of Molecular Engineering and Laboratory of Natural Product Synthesis, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China;4. Jiangsu Key Laboratory of Marine Biotechnology, Huaihai Institute of Technology, Lianyungang 222005, China;1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, People’s Republic of China;2. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, People’s Republic of China;3. Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, People’s Republic of China;4. College of Chemistry and Food Sciences, Yulin Normal University, Yulin 537000, People’s Republic of China;1. Institut fuer Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine Universitaet, Universitaetsstrasse 1, Geb. 26.23., D-40225 Duesseldorf, Germany;2. Vietnamese Academy of Science and Technology, Institute of Chemistry, 18 Hoang Quoc Viet Road, Cau Giay District, Hanoi, Viet Nam;3. Helmholtz Centre for Infection Research, Inhoffenstraße 7, D-38124 Braunschweig, Germany;4. National Research Laboratories of Natural and Biomimetic Drugs, Peking University, Health Science Center, 100083 Beijing, People’s Republic of China;5. Institut fuer Pharmazeutische und Medizinische Chemie, Heinrich-Heine Universitaet, Universitaetsstrasse 1, Geb. 26.23., D-40225 Duesseldorf, Germany;1. Vivekananda Institute of Tropical Mycology, Ramakrishna Mission Vidyapith, Chennai, India;2. Department of Biotechnology, School of Life Sciences, Manipal Academy of Higher Education, Manipal, India;3. PG & Research Department of Botany, Ramakrishna Mission Vivekananda College, Chennai, India |
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| Abstract: | Immunosuppressive activity guided chemical investigation, four alkaloids (1–4) and eight polyketides (5–12) were isolated from mangrove-derived Aspergillus fumigatus HQD24. Their structures were elucidated unambiguously based on the comprehensive spectroscopic analysis and comparison with literature data. Compounds 1 and 3–5 were separated from mangrove endophytic fungi for the first time, 3 and 12 were firstly recovered from fungal genus Aspergillus. Compound 5 remarkable inhibited proliferation of ConA (concanavalin A)-induced T and LPS (lipopolysaccharide)-induced B murine spleen lymphocytes, with IC50 of 12.11 ± 0.11 μM and 62.66 ± 0.80 μM, respectively. Meanwhile, the chemotaxonomic relations of isolated compounds and Aspergillus species were also discussed. |
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| Keywords: | Mangrove endophytic fungi Alkaloids Polyketides Immunosuppressive activity |
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