Isolation of hopane triterpenes and other constituents from Machaerium brasiliense vogel (Fabaceae) |
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| Institution: | 1. Department of Organic Chemistry, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon;2. Centre for Research on Medicinal Plants and Traditional Medicine (CRPMT), Institute of Medical Research and Medicinal Plants Studies (IMPM), P.O. Box 13033 Yaounde, Cameroon;3. Department of Chemistry, Faculty of Science, University of Ngaoundere, P.O. Box 454, Ngaoundere, Cameroon;4. H E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi 75270, Pakistan;1. Shandong Academy of Pharmaceutical Sciences, Jinan 250101, PR China;2. Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, and Key Laboratory of Chemical Engineering and Technology of State Ethnic Affairs Commission, North Minzu University, Yinchuan 750021, PR China;3. Shandong University of Traditional Chinese Medicine, Jinan 250355, PR China;4. College of Pharmacy, Ningxia Medical University, Yinchuan 750004, PR China |
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| Abstract: | Phytochemical study of Machaerium brasiliense leaves extract afforded three hopane triterpenes 3,4-seco-21β-H-hop-22 (29)-en-3-oic acid (1), hopenone B (2), hopene B (3). In addition, lupeol (4), stigmasterol (5), β-sitosterol (6), daucosterol (7), uracil (8), allantoin (9) and trans-4-hydroxy-N-methylproline (10) were isolated. The structures of these compounds were established based on spectroscopic data in comparison to those described in literature. Considering the chemotaxonomic relevance of the isolated compounds, this is the first report of triterpenes 1, 2 and 3 in Fabaceae family and compounds 7, 8 and 9 in the genus Machaerium. Besides, preliminary screening on antiproliferative and antioxidant activities was performed for MBEB and its fractions. |
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| Keywords: | Hopane triterpenes Cytostatic activity Antioxidant activity |
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