Thalidomide attenuates nitric oxide mediated angiogenesis by blocking migration of endothelial cells |
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| Authors: | KP Tamilarasan Gopi Krishna Kolluru Megha Rajaram M Indhumathy R Saranya Suvro Chatterjee |
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| Affiliation: | (1) Vascular Biology Lab, AU-KBC Research Centre, Anna University, Chennai, India;(2) Worked as summer students in June-July 2005. They are B.Tech students from theVivekanandhaa College of Engineering for Women, Tiruchengode, Namakkal, TN, India |
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| Abstract: | Background Thalidomide is an immunomodulatory agent, which arrests angiogenesis. The mechanism of anti-angiogenic activity of thalidomide is not fully understood. As nitric oxide is involved in angiogenesis, we speculate a cross-talk between thalidomide and nitric oxide signaling pathway to define angiogenesis. The aim of present study is to understand the mechanistic aspects of thalidomide-mediated attenuation of angiogenesis induced by nitric oxide at the cellular level. |
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