Radial construction of an arterial wall |
| |
| Authors: | Daniel M Greif Maya Kumar Janet K Lighthouse Justine Hum Andrew An Ling Ding Kristy Red-Horse F Hernan Espinoza Lorin Olson Stefan Offermanns Mark A Krasnow |
| |
| Institution: | Department of Biochemistry, School of Medicine, Stanford University, Stanford, CA 94305, USA; Cardiovascular Division, Department of Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA; Cardiovascular Section, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06511, USA. |
| |
| Abstract: | Some of the most serious diseases involve altered size and structure of the arterial wall. Elucidating how arterial walls are built could aid understanding of these diseases, but little is known about how concentric layers of muscle cells and the outer adventitial layer are assembled and patterned around endothelial tubes. Using histochemical, clonal, and genetic analysis in mice, here we show that the pulmonary artery wall is constructed radially, from the inside out, by two separate but coordinated processes. One is sequential induction of successive cell layers from surrounding mesenchyme. The other is controlled invasion of outer layers by inner layer cells through developmentally regulated cell reorientation and radial migration. We propose that a radial signal gradient controls these processes and provide?evidence that PDGF-B and at least one other signal contribute. Modulation of such radial signaling pathways may underlie vessel-specific differences and pathological changes in arterial wall size and structure. VIDEO ABSTRACT: |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
