Protein evolution: when two become three |
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| Authors: | Pierre Stallforth Jon Clardy |
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| Affiliation: | 1. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02130, USA |
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| Abstract: | Bacterial signaling pathways provide wonderful systems for analyzing protein evolution in?vivo. A systematic dissection of the phosphate-sensing machinery in proteobacteria shows that adaptive, not neutral, mutations disable deleterious crosstalk with closely related signaling systems. |
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