A Ubiquitin-Binding Rhomboid Protease Aimed at ERADication |
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| Authors: | Yien Che Tsai Allan M Weissman |
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| Institution: | Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, 1050 Boyles Street, Frederick, MD?21701, USA. |
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| Abstract: | Proteins are degraded from the ER by endoplasmic reticulum-associated degradation (ERAD). In a recent issue of Molecular Cell, Fleig et?al. (2012) describe a role for a ubiquitin-binding rhomboid protease, RHBDL4, in degradation of select ERAD substrates. These findings and the significance of rhomboids and other intramembrane proteases are discussed. |
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