Synthesis of alpha-helix mimetics with four side-chains |
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| Authors: | Restorp Per Rebek Julius |
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| Affiliation: | The Skaggs Institute for Chemical Biology and Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Rd, MB-26, La Jolla, CA 92037, USA. |
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| Abstract: | The synthesis of a heterocyclic piperazine-based scaffold that mimics the i, i+4, i+8, i+11 side-chain projections of an alpha-helix is described. The synthesis is designed to be modular to allow the targeting of a range of protein-protein interactions involving alpha-helices. |
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