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Synthesis of alpha-helix mimetics with four side-chains
Authors:Restorp Per  Rebek Julius
Affiliation:The Skaggs Institute for Chemical Biology and Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Rd, MB-26, La Jolla, CA 92037, USA.
Abstract:The synthesis of a heterocyclic piperazine-based scaffold that mimics the i, i+4, i+8, i+11 side-chain projections of an alpha-helix is described. The synthesis is designed to be modular to allow the targeting of a range of protein-protein interactions involving alpha-helices.
Keywords:
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