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Local replication of simian immunodeficiency virus in the breast milk compartment of chronically-infected, lactating rhesus monkeys |
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| Authors: | Sallie R Permar Helen H Kang Andrew B Wilks Linh V Mach Angela Carville Keith G Mansfield Gerald H Learn Beatrice H Hahn Norman L Letvin |
| Affiliation: | 1. Institut de Génétique Moléculaire de Montpellier UMR 5535 CNRS, 1919 route de Mende, 34293 Montpellier cedex 5;, Université Montpellier 2, Place Eugène Bataillon, 34095 Montpellier cedex 5; Université Montpellier 1, 5 Bd Henry IV, Montpellier cedex 2, 34967, France 2. Service de Pédiatrie III, Centre Hospitalier Régional Universitaire de Montpellier, H?pital Arnaud de Villeneuve, 371, avenue du Doyen Gaston Giraud, Montpellier cedex 5, 34295, France 3. Laboratoire de virologie, Centre Hospitalier Régional Universitaire de Montpellier, H?pital Saint Eloi, 80 avenue A. Fliche, Montpellier cedex 5, 34295, France 4. Service de chirurgie orthopédique infantile, Centre Hospitalier Régional Universitaire de Montpellier, H?pital Lapeyronie, 371, avenue du Doyen Gaston Giraud, Montpellier cedex 5, 34295, France 5. Institut Cochin, INSERM U1016/CNRS UMR 8104, Université Paris Descartes Paris, France |
| Abstract: | Retroviruses have been linked to a variety of diseases such as neoplastic and immunodeficiency disorders and neurologic and respiratory diseases. Recently, a novel infectious human retrovirus, the xenotropic murine leukemia virus-related virus (XMRV), has been identified in cohorts of patients with either a familial type of prostate cancer or chronic fatigue syndrome. The apparent unrelatedness of these diseases raised the question of the potential involvement of XMRV in other diseases. Here, we investigated the presence of XMRV in a selection of pediatric idiopathic infectious diseases with symptoms that are suggestive of a retroviral infection, as well as in children with respiratory diseases and in adult patients with spondyloarthritis (SpA). Using a XMRV env-nested PCR, we screened 72 DNA samples obtained from 62 children hospitalized in the Montpellier university hospital (France) for hematological, neurological or inflammatory pathologies, 80 DNA samples from nasopharyngeal aspirates from children with respiratory diseases and 19 DNA samples from SpA. None of the samples tested was positive for XMRV or MLV-like env sequences, indicating that XMRV is not involved in these pathologies. |
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