Natural antibodies to IL-2 |
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Authors: | Andrea Balsari Arnaldo Caruso |
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Affiliation: | (1) School of Medicine, Chair of Immunology, University of Milan, Via Venezian 1, 20133 Milan, Italy;(2) Institute of Microbiology, University of Brescia Medical School, Piazzale Spedali Civili, 1, 25124 Brescia, Italy |
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Abstract: | Natural antibodies to human interleukin-2 are present in sera of patients infected with human immunodeficiency virus and also, at a lower titre, in sera of healthy individuals. These antibodies could be purified by affinity-chromatography. Purified human anti-hIL-2 antibodies can interfere with lymphocyte proliferation both in the lymphokine activated killer cell assay and in the mixed lymphocyte culture. The neutralizing activity observedin vitro suggests that these antibodies play a role in the elaborate cytokine network by which the immune system regulates its response. |
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Keywords: | Healty individuals HIV IL-2 natural antibodies neutralizing activity |
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