| 粘附斑激酶(FAK)及其信号通路研究进展 |
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| 引用本文： | 李树裕,王志钢.粘附斑激酶(FAK)及其信号通路研究进展[J].生物技术通报,2009(12). |
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| 作者姓名： | 李树裕 王志钢 |
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| 作者单位： | 内蒙古大学生命科学学院,哺乳动物生殖生物学与生物技术教育部重点实验室,呼和浩特,010021 |
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| 基金项目： | 国家自然科学基金，国家基础科学人才培养基金 |
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| 摘 要： | 粘附斑激酶(focal adhesion kinase,FAK)是一类胞质非受体蛋白酪氨酸激酶,属于蛋白酪氨酸激酶(protein tyrosine kinase)超家族,因而也称为PTKⅡ.FAK在细胞信号转导中处于十分重要的位置,它是胞内外信号出入的中枢,介导多条信号通路.FAK可以整合来自整合素、生长因子以及机械刺激等的信号,激活胞内PI3K/Akt、Ras/MAPK等信号通路,调节细胞生长.FAK还与胚胎发育、肿瘤发生与迁移有关.
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| 关 键 词： | 粘附斑激酶 发育 肿瘤 信号通路 |
Progress in Focal Adhesion Kinase Signaling Pathway |
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| Li Shuyu,Wang Zhigang.Progress in Focal Adhesion Kinase Signaling Pathway[J].Biotechnology Bulletin,2009(12). |
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| Authors: | Li Shuyu Wang Zhigang |
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| Abstract: | Focal adhesion kinase (FAK) is a cytoplasmic nonreceptor protein-tyrosine kinase, belonging to the protein tyrosine kinase superfamily,also called as PTKⅡ. FAK is essential for the cell signal transduction, participates in many "outside-in"and "inside-out" pathways. FAK can integrate signals from integrin, growth factors and mechanical stress, activate the PI3K/Akt and Ras/MAPK pathway, and regulate cell growth. Besides, FAK is tightly linked to the embryonic development, tumorigenesis and migration. |
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| Keywords: | Focal adhesion kinase Development Tumor Signal transduction |
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