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Some properties of the interstrand crosslinks in depurinated DNA |
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| Authors: | Colette Goffin Suzanne Bricteux-Grégoire Walter G. Verly |
| Affiliation: | Laboratoire de Biochimie, Faculté des Sciences, Université de Liège, Sart Tilman B6, 4000 Liège I Belgium |
| Abstract: | The interstrand crosslinks that appear in stored depurinated DNA interfere with the counting of apurinic sites and strand breaks by sucrose gradient analysis. They could not be cleaved at acid or alkaline pH, or by treatment with methoxyamine. |
| Keywords: | DNA damage Interstrand cross-link Apurinic site AP apurinic or apyrimidinic |
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