Tensins: a new switch in cell migration |
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| Authors: | Mouneimne Ghassan Brugge Joan S |
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| Affiliation: | Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. joan_brugge@hms.harvard.edu |
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| Abstract: | Epidermal Growth Factor (EGF) is an important regulator of normal epithelial and carcinoma cell migration. The mechanism by which EGF induces cell migration is not fully understood. A recent report in Nature Cell Biology (Katz et al., 2007) demonstrates that EGF regulates migration through a switch in the expression of two tensin isoforms, weakening the association of beta1 integrin with the actin cytoskeleton in focal adhesions. |
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