Mapping of the SWAP70 gene to mouse Chromosome 7 and human Chromosome 11p15 |
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| Authors: | L. Masat R. A. Liddell B. A. Mock W. -L. Kuo R. Jessberger M. Wabl H.C. Morse III |
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| Affiliation: | (1) Department of Microbiology and Immunology, University of California, San Francisco, CA 94143-0670, USA e-mail: linus@itsa.ucsf.edu Tel.: +1-415-476-6035 Fax: +1-415-4769725, US;(2) Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA, US;(3) Department of Laboratory Medicine, University of California, San Francisco, CA 94143-0670, USA, US;(4) Basel Institute for Immunology, Basel, Switzerland, CH;(5) Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA, US |
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| Abstract: | ![]()
The protein SWAP-70 was isolated as part of a DNA recombination complex in B lymphocytes, where it is predominantly expressed. In resting B cells, SWAP-70 is found in the cytoplasm; upon B-cell activation, it is transported both into the nucleus and to the cell membrane, where it is associated with the B-cell receptor complex and may play a role in signal transduction. In the nucleus, its involvement in heavy-chain class switch recombination has been suggested. In this report, using restriction fragment length polymorphism, simple sequence length polymorphism, and fluorescence in situ hybridization, we map the chromosomal localization of the mouse and the human genes to syntenic regions of mouse mid Chromosome (Chr) 7 and human Chr 11p15. Received: 1 July 1999 / Revised: 28 July 1999 |
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| Keywords: | B lymphocytes Activation Heavy-chain class switch B-cell receptor Signalling protein |
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