革兰氏阴性细菌LuxR/I型群体感应抑制剂研究进展

摘要：细菌群体感应（Quorum sensing, QS）被视为对抗细菌感染与解决细菌耐药性问题的新靶点。以AHLs为信号分子的LuxR/I型群体感应系统广泛存在于革兰氏阴性菌包括多种临床致病菌中，因此寻找LuxR/I型群体感应抑制剂（Quorum sensing inhibitors, QSIs）是研发抗革兰氏阴性致病菌药物的重要途径。迄今为止，已知的LuxR/I型小分子QSIs来源包括化学合成、天然产物与已知药物库的化合物，大分子则包括群体感应淬灭酶与群体感应淬灭抗体。本文总结了近年来LuxR/I型QSIs研究进展，为新型抗菌药物研发提供理论依据。

Research Advances in the LuxR/I Type Quorum Sensing Inhibitors of Gram- Negative Bacteri

ABSTRACT: Research of quorum sensing (QS) is supposed to be a new way to solve bacterial infection and antibiotic resistance problem. The LuxR/I type quorum sensing system with AHLs as signaling molecules are widely existed in the Gram- negative bacteria including many kinds of clinical pathogens. So it is an important approach for developing Gram- negative pathogenic bacteria drugs to exploit the LuxR/I type quorum sensing inhibitors (QSIs). Of the LuxR/I type QSIs that have been discovered so far, the small molecular QSIs include synthetic compounds, natural products, and the compounds screened from known drugs, while the macro-molecule QSIs include the quorum quenching enzymes and the quorum quenching antibodies. This article reviewed the advance of LuxR/I type QSIs discovered in recent years to provide theoretical basis for developing new antibacterial drugs.