DAMPs released by pyroptotic cells as major contributors and therapeutic targets for CAR-T-related toxicities |
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| Authors: | Tian Deng Chao Tang Guizhong Zhang Xiaochun Wan |
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| Affiliation: | 1.Center for Protein and Cell-Based Drugs, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 518055 Shenzhen, People’s Republic of China ;2.Guangdong Immune Cell Therapy Engineering And Technology Research Center (No. 2580 ), Shezhen, People’s Republic of China ;3.Shenzhen BinDeBioTech Co., Ltd., Floor 5, Building 6, Tongfuyu Industrial City, Xili, Nanshan, 518055 Shenzhen, People’s Republic of China |
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| Abstract: | CAR-T transfer, recently well-developed immunotherapy, has offered substantial benefit to more and more patients with advanced cancers. However, along with growing experience in the clinical application comes the increasing awareness of the potentially fatal adverse effects, most notably cytokine release syndrome (CRS) and neurotoxicity. Understanding the mechanisms underlying these toxicities can help to improve therapeutic outcomes. Recent findings highlight the importance of monocyte/macrophage in CAR-T-related toxicities (CARTOX) and shed light on a novel mechanism mediated by damage-associated molecular patterns (DAMPs) released from pyroptotic cells. Therefore, this review summarizes these findings and provides practical guidance to the management of CARTOX.Subject terms: Cell death and immune response, Cancer immunotherapy, Inflammatory diseases |
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