Inhibition by ricin of protein synthesis in vitro: 60S ribosomal subunit as the target of the toxin (Short Communication) |
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Authors: | Simonetta Sperti Lucio Montanaro Alessandro Mattioli Fiorenzo Stirpe |
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Affiliation: | Istituto di Patologia generale dell''Università di Bologna, 40126 Bologna, Italy |
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Abstract: | Poly(U)-directed polyphenylalanine synthesis by rat liver ribosomes is strongly inhibited by ricin. Experiments involving hybridization between subunits derived from normal and ricin-treated ribosomes demonstrate that the 60S subunit is the site of action of the toxin. The toxin inactivates the 60S subunit independently of the presence of the 40S subunit. |
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