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Defining a Canonical Ligand-Binding Pocket in the Orphan Nuclear Receptor Nurr1 |
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| Authors: | Ian Mitchelle S de Vera Paola Munoz-Tello Jie Zheng Venkatasubramanian Dharmarajan David P Marciano Edna Matta-Camacho Pankaj Kumar Giri Jinsai Shang Travis S Hughes Mark Rance Patrick R Griffin Douglas J Kojetin |
| Institution: | 1. Department of Integrative Structural and Computational Biology, The Scripps Research Institute, Jupiter, FL 33458, USA;2. Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL 33458, USA;3. Skaggs Graduate School of Chemical and Biological Sciences, The Scripps Research Institute, Jupiter, FL 33458, USA;4. Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, OH 45267, USA |
| Abstract: |  |
| Keywords: | orphan nuclear receptor Nurr1 NR4A2 ligand binding dynamic pocket unsaturated fatty acids NMR spectroscopy hydrogen deuterium exchange mass spectrometry molecular dynamics simulations |
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