Targeting and sensing cancer cells with ZnO nanoprobes in vitro |
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Authors: | Sudhagar Selvaraj Sathya Shanmugaraj Pandian Kannaiyan Lakshmi Baddireddi Subhadra |
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Institution: | (1) Tissue Culture and Drug Discovery Laboratory, Centre for Biotechnology, Anna University, Chennai, 600 025, India;(2) Department of Inorganic Chemistry, University of Madras, Chennai, 600 025, India |
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Abstract: | A new class of zinc oxide quantum dots (ZnO QDs) was investigated as nanoprobes for targeting cancer cells in vitro. ZnO nanoparticles
were synthesized using conventional sol–gel method and encapsulated using trimethoxy aminopropyl silane. Transferrin, the
ligand targeting the cancer cells, was conjugated to the ZnO QDs. In vitro imaging studies using MDA-MB-231 showed the biocompatible
ZnO nanoprobe selectively binding to the cell surface receptor and internalizing through receptor-mediated endocytosis. Time-lapsed
photobleaching studies indicate the ZnO QDs to be resistant to photobleaching, making them suitable for long term imaging
purpose. Investigation of the ZnO nanoprobe as a platform for sensitive bioassays indicates that it can be used as an alternative
fluoroprobe for cancer cell targeting and sensing applications. |
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