The efficacy of Link N as a mediator of repair in a rabbit model of intervertebral disc degeneration |
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| Authors: | Fackson Mwale Koichi Masuda Rajeswari Pichika Laura M Epure Tomoaki Yoshikawa Aseem Hemmad Peter J Roughley John Antoniou |
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| Institution: | (1) Division of Orthopaedic Surgery, McGill University, 1650 Cedar Avenue, Montreal, QC, Canada, H3G 1A4;(2) Lady Davis Institute for Medical Research, SMBD-Jewish General Hospital, 3755 Chemin de la Cote Ste-Catherine, Montreal, QC, Canada, H3T 1E2;(3) Department of Orthopaedic Surgery, School of Medicine, University of California, San Diego, 9500 Gilman Drive, Mail Code 0863, La Jolla, CA 92093-0863, USA;(4) Genetics Unit, Shriners Hospitals for Children, 1529 Cedar Avenue, Montreal, QC, Canada, H3G 1A6 |
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| Abstract: | Introduction Intervertebral disc (IVD) degeneration is associated with proteolytic degradation of the extracellular matrix, and its repair
requires both the production of extracellular matrix and the downregulation of proteinase activity. These properties are associated
with several growth factors. However, the use of growth factors in clinical practice is limited by their high cost. This cost
can be circumvented using synthetic peptides, such as Link N, which can stimulate the synthesis of proteoglycan and collagen
by IVD cells in vitro. The purpose of the present study was to evaluate the effect of Link N in vivo in a rabbit model of IVD degeneration. |
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