Human molecular genetics: from monogenic to polygenic or complex disorders |
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| Authors: | Rousseau François Laflamme Nathalie |
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| Institution: | Unité de recherche en génétique humaine et moléculaire, Centre de recherche de l'h?pital St-Fran?ois-d'Assise du CHUQ, Université Laval, 10, rue de l'Espinay, Québec G1L 3L5, Canada. |
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| Abstract: | Human molecular genetics has successfully identified the genes involved in several monogenic disorders. It now aims at pinpointing the genetic determinants of polygenic or complex traits with a strong genetic component. This constitutes a new challenge. We discuss the methodological and practical aspects of identifying such genes as well as the challenges facing physicians that will have to use efficiently these new diagnostic tools. |
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