Respiratory system of Fusidium coccineum and regulation of biosynthesis of fusidic acid and sporogenesis |
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Authors: | S M Navashin Yu E Bartoshevich G N Telesnina R A Zvjagilskaya S V Dmitriyeva Yu O Sazykin I N Krakhmaleva |
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Institution: | (1) All-Union Research Institute of Antibiotics, A. N. Bakh Institute of Biochemistry, Academy of Sciences of the USSR, Nagatinskaya St. 3a, M-105 Moscow, USSR |
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Abstract: | Summary The respiratory system, sporulation, and dynamics of alkaline protease formation were studied in three strains of the fungus Fusidium coccineum, differing in their ability to make antibiotics.Oxidative phosphorylation provided most of the energy in high and low activity strains and their respiratory activity was exclusively related to mitochondria functioning.In inactive and low activity strains, the terminal oxidation of reduced equivalents proceeds mainly by the respiratory chain with cytochrome oxidase as the terminal component. In the high activity strain there is a cyanide-resistant alternative pathway which is parallel to the classical cytochrome chain. The complete transition to the use of this pathway coincides with the stage of maximum antibiotic biosynthesis. The induction of the alternative pathway in the high activity strain was not concerned with the inhibition of the cytochrome site of the respiratory chain by fusidic acid. It was shown that the quantity of the antibiotic synthesized and the character of cellular differentiation can be altered by changing the oxidation pathwats used with inhibitors such as chloramphenicol and salicyl hydroxamate.We suggest that there must be common regulation of antibiotic formation, sporulation and induction of the alternative oxidation pathway. |
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