Glutathione Peroxidase 1, Selenoprotein K,and Selenoprotein H May Play Important Roles in Chicken Testes in Response to Selenium Deficiency |
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| Authors: | Yuhong Gao Jiuli Zhang Xiaodan Huang Guixue Zhang |
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| Affiliation: | 1.Department of Biology, Ashkezar Branch,Islamic Azad University,Ashkezar,Iran;2.Department of Gynecology and Obstetrics,School of Medicine, Kashan University of Medical Sciences,Kashan,Iran;3.Medical Biotechnology Research Center, Ashkezar Branch,Islamic Azad University,Ashkezar,Iran;4.Department of Gynecology and Obstetrics,School of Medicine, Iran University of Medical Sciences,Tehran,Iran;5.Department of Gynecology and Obstetrics,School of Medicine, Bushehr University of Medical Sciences,Bushehr,Iran;6.Research Center for Biochemistry and Nutrition in Metabolic Diseases,Kashan University of Medical Sciences,Kashan,Iran;7.Department of Gynecology and Obstetrics,Endocrinology and Metabolism Research Center, School of Medicine, Arak University of Medical Sciences,Arak,Iran;8.Present address: Department of Nutrition,Kashan University of Medical Sciences,Kashan,Iran |
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| Abstract: | The current study was designed to determine the beneficial effects of zinc supplementation on expressed levels of peroxisome proliferator-activated receptor gamma (PPAR-γ) and glucose transporter type 1 (GLUT1) genes in newborns of women with gestational diabetes mellitus (GDM). This randomized, double-blind, placebo-controlled clinical trial was performed among 40 women with GDM. Patients were randomly allocated to intake either 233 mg zinc gluconate (containing 30 mg zinc) (n?=?20) or a placebo (n?=?20) for 6 weeks. PPAR-γ and GLUT1 mRNA levels were quantified in umbilical cord blood of newborns of women with GDM. After 6 weeks of intervention, the change in serum zinc levels was greater in women consuming zinc than in the placebo group (+11.1?±?13.4 vs. ?4.8?±?17.3 mg/dL, P?=?0.002). Quantitative results of RT-PCR demonstrated that compared with the placebo, zinc supplementation resulted in a significant increase of expressed levels of PPAR-γ mRNA (P?P?
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