Content of Minerals and Fatty Acids and Their Correlation with Phytochemical Compounds and Antioxidant Activity of Leguminous Seeds |
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| Authors: | Eugeniusz R Grela Wioletta Samolińska Bożena Kiczorowska Renata Klebaniuk Piotr Kiczorowski |
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| Institution: | 1.Health Service Vocational School of Higher Education,University of Giresun,Giresun,Turkey;2.Faculty of Veterinary Science, Department of Biochemistry,University of Yüzüncü Y?l,Van,Turkey;3.Faculty of Veterinary Science, Department of Physiology,University of Yüzüncü Y?l,Van,Turkey;4.Fethiye School of Health, Department of Nutrition and Dietetics,University of Mu?la S?tk? Ko?man,Mu?la,Turkey |
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| Abstract: | This study was carried out to determine the effect of zinc on oxidative DNA damage in rats with experimental acute and chronic kidney deficiency. Six groups of five Wistar-Albino rats each were assigned as controls (C), acute kidney deficiency (AKD), zinc-supplemented (+Zn), acute kidney deficiency, zinc-supplemented (AKD + Zn), chronic kidney deficiency (CKD) and zinc-supplemented chronic kidney deficiency (CKD + Zn). The levels of 8-Oxo-2′-deoxyguanosine (8-OHdG) were determined, being the lowest in the CKD group (p < 0.05), higher in the C group than those of rats with CKD but lower than that of all the other groups (p < 0.05). There were no significant differences between the controls and the CKD + Zn group, or between the AKD and the +Zn groups. Among all groups, the highest 8-OHdG level was found in the AKD + Zn group (p < 0.05). DNA damage was greater in acute renal failure than in rats with chronic renal failure. The DNA damage in the zinc group was significantly higher than in the controls. |
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