Asparagine-linked sugar chains of erythrocyte membrane glycoproteins from Wiskott-Aldrich syndrome are not impaired |
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Authors: | Naomi Kondo Fumiaki Motoyoshi Tadao Orii |
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Institution: | (1) Department of Pediatrics, Gifu University School of medicine, Tsukasa-machi 40, 500 Gifu, Japan |
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Abstract: | In both healthy controls and patients with Wiskott-Aldrich syndrome, the main oligosaccharide in asparagine-linked sugar chains of the membrane glycoproteins of erythrocytes was biantennary sugar chain with bisected G1cNAc (Gal2-GlcNAc2-Man3-GlcNAc-GlcNAc-Fuc-GlcNAcOT). Biantennary sugar chain with an -fucosyl residue linked at the proximal GlcNAc was seen but biantennary sugar chain without an -fucosyl residue at the proximal GlcNAc was not detected in each subject. There was no difference in quality and quantity of asparagine-linked sugar chains of erythrocyte membrane glycoproteins between healthy controls and the patients. These results suggest that asparagine-linked sugar chains in membrane glycoproteins of hematopoietic cells may not be impaired in Wiskott-Aldrich syndrome. |
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Keywords: | asparagine-linked sugar chains erythrocytes membrane glycoproteins Wiskott-Aldrich syndrome |
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