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Antiproliferative effect of D-glucuronyl C5-epimerase in human breast cancer cells |
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| Authors: | Tatiana Y Prudnikova Liudmila A Mostovich Natalia V Domanitskaya Tatiana V Pavlova Vladimir I Kashuba Eugene R Zabarovsky Elvira V Grigorieva |
| Affiliation: | (1) Institute of Molecular Biology and Biophysics SD RAMS, Timakova str., 2, 630117 Novosibirsk, Russia;(2) MTC, Department of Clinical Science and Education, Sodersjukhuset, Karolinska Institute, Nobels vag 16, 17177 Stockholm, Sweden;(3) Institute of Molecular Biology and Genetics, UNAS, Zabolotnogo str., 150, 03680 Kiev, Ukraine;(4) Engelhard Institute of Molecular Biology RAS, Vavilova str., 32, 119991 Moscow, Russia |
| Abstract: | BackgroundD-glucuronyl C5-epimerase (GLCE) is one of the key enzymes in the biosynthesis of heparansulfate proteoglycans. Down-regulation of GLCE expression in human breast tumours suggests a possible involvement of the gene in carcinogenesis. In this study, an effect of GLCE ectopic expression on cell proliferation and viability of breast carcinoma cells MCF7 in vitro and its potential molecular mechanisms were investigated. |
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