Isoxazoline GPIIb/IIIa antagonists bearing a phosphoramidate |
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| Authors: | Wityak J Tobin A E Mousa S A Wexler R R Olson R E |
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| Affiliation: | DuPont Pharmaceuticals Company, Wilmington, Delaware 19880-0500, USA. |
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| Abstract: | Isoxazolinylacetamides bearing a phosphoramidate group alpha- to the carboxylate moiety (3) were prepared and evaluated for in vitro antiplatelet efficacy. They were found to bind GPIIb/IIIa with high affinity and were potent antagonists of ADP mediated platelet aggregation. |
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