Isoflavones inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase in vitro |
| |
| Authors: | Sung Jang Hoon Lee Sung-Joon Park Kwan Hwa Moon Tae Wha |
| |
| Institution: | Department of Food Science and Technology, School of Agricultural Biotechnology, and Center for Agricultural Biomaterials, Seoul National University, Korea. |
| |
| Abstract: | Isoflavones identified as inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase in soybean paste were assayed using the catalytic portion of Syrian hamster HMG-CoA reductase, and the kinetic values were measured using HMG-CoA and NADPH. The inhibition of HMG-CoA reductase by these inhibitors was competitive with HMG-CoA and noncompetitive with NADPH. Ki values for genistein, daidzein, and glycitein were 27.7, 49.5, and 94.7 microM, respectively. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
