Reduced sensitivity of the heart ventricle of obese Zucker rats to isoprenaline |
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| Authors: | C Vernimmen M C Auclair P Lechat |
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| Institution: | Institut de Pharmacologie et Unité n. 228 I.N.S.E.R.M., Paris. |
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| Abstract: | In heart of genetically obese (fa/fa) 12-week-old Zucker rats, ventricle contractility (4 mM KCl medium), amplitude and duration of slow action potentials (14 mM KCl medium) were less increased by isoprenaline than in heart of non obese (Fa/fa) rats. This difference could be related to a lower reactivity of beta-adrenoceptors in obese rat heart. |
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