Enantioselective oxidations of sulfides catalyzed by chloroperoxidase |
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| Authors: | S Colonna N Gaggero A Manfredi L Casella M Gullotti G Carrea P Pasta |
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| Affiliation: | Dipartimento di Chimica Organica e Industriale, Università di Milano, Italy. |
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| Abstract: | The chloroperoxidase-catalyzed and horseradish peroxidase catalyzed oxidations of sulfides by tert-butyl and other peroxides have been investigated. The former metal enzyme afforded the corresponding sulfoxides having R absolute configuration in up to 92% enantiomeric excess (ee), whereas the latter gave racemic products. The various factors that control the enantioselectivity of the oxygenation have been examined. |
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