Discovery and synthesis of novel substituted benzocoumarins as orally active lipid modulating agents |
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Authors: | Sashidhara Koneni V Kumar Manoj Modukuri Ram K Srivastava Anuj Puri Anju |
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Affiliation: | Medicinal and Process Chemistry Division, Central Drug Research Institute (CSIR-CDRI), Lucknow 226 001, India. kv_sashidhara@cdri.res.in |
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Abstract: | The synthesis of a series of benzocoumarin keto-enamine schiff bases is reported. The novel compounds were evaluated for their antihyperlipidemic activity in the hyperlipidemic hamster model. The compound 11 at a dose of 10 mg/kg body weight significantly lowered the plasma triglyceride levels (TG) by 70%, total cholesterol (TC) by 47%, accompanied by an increase in HDL-C/TC ratio by 80% in hyperlipidemic hamsters to a greater degree than the reference drugs atorvastatin and lovastatin. |
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Keywords: | Synthesis Benzocoumarin Statins Antidyslipidemic |
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