|
|||||
|
|
Synthesis and structure-activity relationship studies of dihydronaphthyridinediones as a novel structural class of potent and selective PDE7 inhibitors |
|
| Authors: | Gewald Rainer Rueger Carla Grunwald Christian Egerland Ute Hoefgen Norbert |
| Affiliation: | biocrea GmbH, Meissner Strasse 191, 01445 Radebeul, Germany. rainer.gewald@biocrea.com |
| Abstract: | The synthesis and SAR studies of a series of structurally novel inhibitors of PDE7 are discussed. The best compounds from the series display low nanomolar inhibitory activity and are selective versus other PDE isoenzymes. |
| Keywords: | PDE7 inhibitor Phosphodiesterase Dihydronaphthyridinedione Structure-activity relationship Molecular docking |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |