Evaluation of subsampling-based normalization strategies for tagged high-throughput sequencing data sets from gut microbiomes |
| |
| Authors: | Cárcer Daniel Aguirre de Denman Stuart E McSweeney Chris Morrison Mark |
| |
| Affiliation: | CSIRO Preventative Health National Research Flagship and Division of Livestock Industries, Queensland Bioscience Precinct, St. Lucia, QLD 4067, Australia. |
| |
| Abstract: | Several subsampling-based normalization strategies were applied to different high-throughput sequencing data sets originating from human and murine gut environments. Their effects on the data sets' characteristics and normalization efficiencies, as measured by several β-diversity metrics, were compared. For both data sets, subsampling to the median rather than the minimum number appeared to improve the analysis. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
