Optimized synthesis of phosphatidylserine |
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Authors: | Giuseppe Guanti L. Banfi A. Basso L. Bondanza G. Guglieri K. Powles R. Riva |
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Affiliation: | 1. Dipartimento di Chimica e Chimica Industriale, Università di Genova, via Dodecaneso 31, 16146, Genoa, Italy
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Abstract: | The synthesis of phosphatidyl serine containing saturated fatty acids was thoroughly studied and optimized in order to establish a protocol amenable to large-scale synthesis. The key step was a one-pot multicomponent reaction involving an O-benzyl phosphorodiamidite, protected serine and diacylglycerol, followed by in situ oxidation of the resulting phosphite. In order to replace expensive and poorly stable tetrazole, a screening of substitutes was carried out and imidazolium chloride was selected as the best suited one. |
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