Restricted Transport of Vitamin D and A Derivatives Through the Rat Blood-Brain Barrier |
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| Authors: | William M Pardridge Roland Sakiyama William A Coty |
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| Institution: | Departments of Medicine and Biological Chemistry, UCLA School of Medicine, Los Angeles, California, U.S.A. |
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| Abstract: | The present studies measure the transport of retinol, retinoic acid, 1,25-dihydroxyvitamin D3 1,25-(OH)2D3], and 25-hydroxyvitamin D3 25-(OH)D3] through the rat brain capillary endothelial wall, i.e., the blood-brain barrier (BBB). The vitamin A and D derivatives bind both to albumin and to specific high-affinity binding proteins in plasma. In the presence of physiologic concentrations of plasma proteins, the extraction by brain of all four compounds was 5% or less. |
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| Keywords: | Retinol-binding protein Vitamin D-binding protein Albumin |
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