Optimal policies of non-cross-resistant chemotherapy on Goldie and Coldman’s cancer model |
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| Authors: | Jeng-Huei Chen Ya-Hui KuoHsing Paul Luh |
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| Affiliation: | Department of Mathematical Sciences, National Chengchi University, Taipei, Taiwan |
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| Abstract: | Mathematical models can be used to study the chemotherapy on tumor cells. Especially, in 1979, Goldie and Coldman proposed the first mathematical model to relate the drug sensitivity of tumors to their mutation rates. Many scientists have since referred to this pioneering work because of its simplicity and elegance. Its original idea has also been extended and further investigated in massive follow-up studies of cancer modeling and optimal treatment. |
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| Keywords: | Goldie and Coldman&rsquo s model Drug resistance Optimal cancer treatment |
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