Synthesis and Biological Activity of Nitrilic Derivatives of the Methyl Ester of Maleopimaric Acid |
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| Authors: | E. V. Tret’yakova E. V. Salimova L. V. Parfenova |
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| Affiliation: | 1.Institute of Petrochemistry and Catalysis,Russian Academy of Sciences,Ufa,Russia |
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| Abstract: | An effective method of a modification of the anhydride ring of the maleopimaric acid methyl ester by means of the cyanoethylation reaction was developed. A primary screening of a cytotoxic activity in vitro demonstrated an ability of the cyanoethyl derivative of the maleopimaric acid methyl ester to induce the death of the PC-3 cells of prostate cancer. |
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