| Abstract: | The cease of aeration of UV-irradiated bacteria incubated in glucose-salt medium does not affect antimutagenic activity of excision repair in Escherichia coli cells but strongly inhibits that in Bacillus subtilis cells. It has been suggested that these differences are connected with various possibilities for energy (ATP) production in facultative anaerobe, which is E. coli, and obligate anaerobe, Bac. subtilis. The absence of noticeable influence of the aerobiosis----anaerobiosis shift on the kinetics of disappearance of potential mutations in E. coli cells is interpreted in terms of existence of a mechanism regulating the expenditure of cell energy reserve upon repair process. It is suggested that the low rate of disappearance of potential mutations observed in post-irradiation conditions favourable for protein synthesis is a consequence of limited supply of energy to repair process at some sites of cellular DNA, due to great expense of energy for protein synthesis. |
